197250-15-0
中文名称
GAP26
英文名称
GAP 26
CAS
197250-15-0
分子式
C70H107N19O19S
分子量
1550.78
MOL 文件
197250-15-0.mol
更新日期
2024/04/26 10:50:34
197250-15-0 结构式
基本信息
中文别名
VR-13化合物GAP 26
英文别名
GAP 26GAP-26
GAP26
43Gap 26, Connexin Mimetic
M.W. 1550.78 C70H107N19O19S
Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg
GAP 26/Connexin 43 (63-75) (human, bovine, mouse, rat), Gap Junction α-1 Protein (63-75)
L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-
所属类别
生物化工：激动剂抑制剂物理化学性质
密度1.47±0.1 g/cm3(Predicted)
储存条件Keep in dark place,Inert atmosphere,2-8°C
溶解度insoluble in EtOH; ≥155.1 mg/mL in H2O with ultrasonic; ≥77.55 mg/mL in DMSO with gentle warming and ultrasonic
酸度系数(pKa)3.31±0.10(Predicted)
形态固体
水溶解性Soluble to 2 mg/ml in water
序列H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH
GAP26价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-P1082 | GAP26 Gap 26 | 197250-15-0 | 1mg | 900元 |
| 2024/01/25 | HY-P1082 | GAP26 Gap 26 | 197250-15-0 | 5mg | 1800元 |
| 2024/01/25 | HY-P1082 | GAP26 Gap 26 | 197250-15-0 | 10mg | 2800元 |
常见问题列表
生物活性
Gap 26 是一种连接蛋白模拟肽，由连接蛋白connexin 43 (Cx43)的细胞外环1的残基 no. 63-75组成，是 gap junction 的抑制剂。Gap 26 可阻止光解inositol-1,4,5-trisphosphate触发的ATP释放。靶点
| Target | Value |
|
gap junction
() |
体外研究
Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected.
Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used.
Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC
50
of 28.4 ± 3.4 μM.