207277-66-5

中文名称 207277-66-5

CAS 207277-66-5

分子式 C27H29NO3

分子量 415.52

MOL 文件 207277-66-5.mol

207277-66-5 结构式

基本信息物理化学性质常见问题列表

基本信息

英文别名

NNC45-0781
2H-1-Benzopyran-7-ol, 3,4-dihydro-3-phenyl-4-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-, (3S,4R)-

物理化学性质

沸点563.7±50.0 °C(Predicted)

密度1.185±0.06 g/cm3(Predicted)

酸度系数(pKa)9.87±0.60(Predicted)

常见问题列表

生物活性

NNC45-0781 是一种组织选择性的雌激素 (estrogen) 部分激动剂。

靶点

Estrogen Receptor

体内研究

NNC45-0781 (NNC 45-0781) shows that it is a very promising tissue-selective estrogen agonist. Total serum cholesterol is significantly increased in the vehicle-treated group as compared to the sham animals. All of the animals receiving NNC45-0781 at doses of 10 nmol/g or higher, has significantly lower levels of total serum cholesterol as compared to the vehicle treated group.