210821-63-9
中文名称
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
英文名称
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
CAS
210821-63-9
分子式
C10H11ClF3N3.ClH
分子量
302.126
MOL 文件
210821-63-9.mol
210821-63-9 结构式
基本信息
中文别名
化合物 T23110 英文别名
Org 12692Org12962HCl
Org 12962 hydrochloride
1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazinehydrochloride
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
常见问题列表
生物活性
Org 12962 hydrochloride 是一种有效的、选择性的 5-HT2C 受体激动剂，对 5-HT2C，5-HT2A，5-HT2B 的 pEC50 分别为 7.01、6.38 和 6.28。Org 12962 hydrochloride 在焦虑大鼠的模型中显示出缓解作用。靶点
|
5-HT 2C Receptor 7.01 (pEC 50 ) |
5-HT 2A Receptor 6.38 (pEC 50 ) |
5-HT 2B Receptor 6.28 (pEC 50 ) |
体内研究
Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F 3.71 =11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects.
| Animal Model: | Male Wistar rats |
| Dosage: | 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg |
| Administration: | Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg |
| Result: | Had a dose-related antipanic-like effect in SD-rat. |