| Identification | Back Directory | [Name]
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride | [CAS]
210821-63-9 | [Synonyms]
Org 12692
Org12962HCl
Org 12962 hydrochloride
1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazinehydrochloride
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride | [Molecular Formula]
C10H11ClF3N3.ClH | [MOL File]
210821-63-9.mol | [Molecular Weight]
302.126 |
| Hazard Information | Back Directory | [Uses]
Org 12962 Hydrochloride is a receptor agonists that helps in the anxiety models in rats. | [Biological Activity]
Selective 5-HT 2C receptor agonist (pEC 50 values are 7.01, 6.38 and 6.28 for 5-HT 2C , 5-HT 2A and 5-HT 2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety. | [in vivo]
Org 12962 (intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3]. | Animal Model: | Male Wistar rats[3] | | Dosage: | 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg | | Administration: | Intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg | | Result: | Had a dose-related antipanic-like effect in SD-rat. |
| [IC 50]
5-HT2C Receptor: 7.01 (pEC50); 5-HT2A Receptor: 6.38 (pEC50); 5-HT2B Receptor: 6.28 (pEC50) | [storage]
Desiccate at RT |
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Energy Chemical
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http://www.energy-chemical.com |
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cjbscvictory
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13348960310 |
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https://www.weikeqi-biotech.com/ |
| Company Name: |
Enzo Biochem Inc
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Enzo Biochem Inc. 13797054060 |
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www.enzo.com |
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