2152-44-5
中文名称
倍他米松戊酸酯
英文名称
Betamethasone 17-valerate
CAS
2152-44-5
EINECS 编号
218-439-3
分子式
C27H37FO6
MDL 编号
MFCD00867446
分子量
476.58
MOL 文件
2152-44-5.mol
更新日期
2024/09/25 08:45:26
2152-44-5 结构式
基本信息
中文别名
倍他米松戊酸酯戊酸倍他米松
倍他米松戊酸盐
7戊酸倍他米松
英文别名
1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17-VALERATE1,4-pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate
1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-9ALPHA-FLUORO-16BETA-METHYL-3,20-DIONE 17-VALERATE
9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17-VALERATE
9ALPHA-FLUORO-16BETA-METHYLPREDNISOLONE 17-VALERATE
9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate
BEDERMIN
BETAMETHASONE 17ALPHA-VALERATE
BETAMETHASONE 17A-VALERATE
BETAMETHASONE 17-VALERATE
BETAMETHASONE VALERATE
BETNESOL-V
BETNEVAL
BETNOVATE
VALISONE
(11-beta,16-beta)-l)oxy)
17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione-9-fluoro-11-bet
17-valerate
Betamethasonevalerateester
betnovateat
所属类别
原料药:肾上腺皮质激素类药物理化学性质
外观性状倍他米松戊酸酯(2152-44-5)为白色晶体或粉末,比旋光度+75°~+82°
熔点183-184°
比旋光度D +77° (dioxane)
沸点598.9±50.0 °C(Predicted)
密度1.1174 (estimate)
储存条件2-8°C
溶解度Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
酸度系数(pKa)12.90±0.70(Predicted)
形态neat
颜色白色
Merck13,1183
BRN4240001
InChIKeySNHRLVCMMWUAJD-SUYDQAKGSA-N
SMILES[C@]12(C)C[C@@H]([C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@@]3([H])[C@]1([H])C[C@H](C)[C@@]2(C(=O)CO)OC(=O)CCCC)O |&1:0,3,4,6,16,18,21,23,r|
安全数据
警示词危险
危险性描述H360D-H373
危险品标志Xn
危险类别码R48
安全说明S22-S24/25
危险品运输编号UN 2811 6.1/PG 3
WGK Germany2
RTECS号TU3835000
海关编码29372290
毒性mouse,LD50,intraperitoneal,632mg/kg (632mg/kg),Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
常见问题列表
用途
倍他米松戊酸酯主要是用于皮肤类炎症的外用药,抑制和减轻皮肤的 瘙痒,红肿等症状,如湿疹,牛皮癣和皮炎。倍他米松戊酸酯属于高效皮质激素具有易吸收,副作用小的特点。
生物活性
Betamethasone Valerate 是一种中等强效的糖皮质激素类固醇,具有抗炎和免疫抑制特性。靶点
Target | Value |
Glucocorticoid Receptor
() |
体内研究
Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy.
Betamethasone-17-valerate ointment (50 mg) inhibits homologous passive cutaneous anaphylaxis.
Animal Model: | Female Sprague-Dawley rats weighing 60-70 g (croton oil edema experiment) |
Dosage: | 10 mg |
Administration: | Applied to the irritated site with a micro spatula; 5 minutes |
Result: | Inhibited about 50% of the ear edema without thymus atrophy. |