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217799-03-6

中文名称 217799-03-6
英文名称 KP496
CAS 217799-03-6
分子式 C31H34ClN3O7S3
分子量 692.27
MOL 文件 217799-03-6.mol
217799-03-6 结构式 217799-03-6 结构式

基本信息

中文别名
化合物 T11764
英文别名
KP496
Benzoic acid, 2-[[[4-[[(4-chlorophenyl)sulfonyl]amino]butyl][[3-[[4-(1-methylethyl)-2-thiazolyl]methoxy]phenyl]methyl]amino]sulfonyl]-

物理化学性质

沸点847.9±75.0 °C(Predicted)
密度1.378±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)3.09±0.36(Predicted)
形态Solid
颜色White to off-white
217799-03-6价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2025/05/22HY-U00253KP496217799-03-61 mg3000元
2025/05/22HY-U00253KP496217799-03-610 mM * 1 mLin DMSO10356元
2024/08/19HY-U00253217799-03-6
KP496
217799-03-65mg8500元

常见问题列表

生物活性
KP49 是一个有选择性的 Leukotriene D4 and Thromboxane A2 受体的双重拮抗剂。
靶点

LTD 4

TXA 2 Receptor

体内研究

KP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation. KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively. The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents.

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