返回ChemicalBook首页>CAS数据库列表>220810-26-4

220810-26-4

中文名称 醋酸组氨瑞林
英文名称 Vantas
CAS 220810-26-4
分子式 C66H86N18O12
分子量 1323.52
MOL 文件 220810-26-4.mol
更新日期 2025/05/17 17:21:51
220810-26-4 结构式 220810-26-4 结构式

基本信息

中文别名
组氨瑞林乙酸盐
醋酸组氨瑞林杂质
英文别名
Vantas
Supprelin la
Vantas USP/EP/BP
Histrelin acetate, >=98%
Histrelin Acetate(acetate)
Histrelin?Acetate impurity
(Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
所属类别
生物化工:多肽

物理化学性质

储存条件-20°C储存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml
形态结晶固体
颜色White to off-white

应用领域

用途一
Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor). It stimulates release of oxytocin and vasopressin ex vivo from the isolated rat hypothalamo-neurohypophysial system at a concentration of 100 nM. In vivo, the initial dose of histrelin (100 μg) stimulates acute increases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels (50-, 2.5-, and 15-fold, respectively), while chronic treatment leads to 95% decreases in LH and FSH responses in rhesus monkeys. Formulations containing histrelin have been used in the treatment of advanced prostate cancer and central precocious puberty.

常见问题列表

概述
醋酸组氨瑞林 一种 GnRH 类似物,是一种 GnRH 受体激动剂。Histrelin acetate 可增加血清中促黄体激素(LH)、促卵泡激素 (FSH) 和睾酮水平。Histrelin acetate 可用于前列腺癌、子宫内膜异位症的研究。
"220810-26-4" 相关产品信息
24593-59-7 4289-02-5 145781-92-6 60189-34-6 116430-60-5 114466-38-5 151126-32-8 3397-23-7 28575-34-0 34973-08-5 66002-66-2 62288-83-9 183552-38-7 158861-67-7 148031-34-9 62568-57-4 120287-85-6 140194-24-7