2227-64-7

基本信息
3-硝基-α-溴代苯乙酮
Α-溴代间硝基苯乙酮
α-溴间硝基苯乙酮
溴代间硝基苯乙酮
&-溴-3'-硝基苯乙酮
3-硝基苯酰甲基溴
Α-溴代间硝基苯乙酮
Α-溴间硝基苯乙酮
&-溴-3'-硝基苯乙酮
2-BROMO-1-(3-NITRO-PHENYL)-ETHANONE
2-BROMO-3'-NITROACETOPHENONE
3'-NITRO-2-BROMO ACETOPHENONE
3-NITRO-ALPHA-BROMOACETOPHENONE
3'-NITROPHENACYL BROMIDE
3-NITROPHENACYL BROMIDE
A-BROMO-3-NITROACETOPHENONE
A-BROMO-M-NITROACETOPHENONE
AKOS BBS-00003963
ALPHA-BROMO-3'-NITROACETOPHENONE
LABOTEST-BB LT00233190
M-NITROPHENACYL BROMIDE
Acetophenone, 2-bromo-3'-nitro-
alpha-Bromo-m-nitroacetophenone
-Bromo-3-nltroacetopheone
Ethanone, 2-bromo-1-(3-nitrophenyl)-
omega-Bromo-m-nitroacetophenone
a-Bromo-3itroacetophenone
3-Nitrophenacylbromide, 97+
物理化学性质
制备方法

121-89-1

2227-64-7
以间硝基苯乙酮为原料合成2-溴-3'-硝基苯乙酮的一般步骤如下:制备2-溴-1-(3-硝基苯基)乙酮(2a-1)。向市售3-硝基苯乙酮(4.82 g,29.19 mmol)的无水乙醚(25 mL)悬浮液中加入氯化铝(0.16 g,1.20 mmol)。将反应混合物冷却至0℃,随后缓慢滴加溴(1.50 mL,29.19 mmol)。反应混合物在室温下搅拌1小时,直至原料完全转化(通过1H NMR监测),并迅速淬灭反应以避免二溴化物的形成。加入水(30 mL)后,用乙醚(3×30 mL)萃取混合物,并用无水硫酸镁干燥,得到化合物2a-1,为黄褐色固体(5.73 g,收率97%)。1H NMR(CDCl3, 200 MHz):δ 4.50(s, 2H, H1),7.73(t, J = 8.0 Hz, 1H, H7),8.31(ddd, J = 7.8, 1.7, 1.1 Hz, 1H, H8),8.43(ddd, J = 8.2, 2.3, 1.1 Hz, 1H, H6),8.76(t, J = 1.9 Hz, 1H, H4)。13C NMR(CDCl3, 200 MHz):δ 30.4, 123.9, 128.2, 130.4, 134.6, 135.2, 148.6, 189.5。MS-ESI(m/z):[M + H]+ = 244.9。
参考文献:
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 18, p. 8276 - 8292
[2] Patent: WO2017/17004, 2017, A1. Location in patent: Page/Page column 17
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 10, p. 2192 - 2196
[4] Tetrahedron Letters, 2011, vol. 52, # 31, p. 4026 - 4029
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 10, p. 1424 - 1430
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2025/05/22 | 13747 | 2-溴-3'-硝基苯乙酮 2-Bromo-3'-nitroacetophenone, 97%, Thermo Scientific Chemicals | 2227-64-7 | 5g | 447元 |
2025/05/22 | 13747 | 2-溴-3'-硝基苯乙酮 2-Bromo-3'-nitroacetophenone, 97%, Thermo Scientific Chemicals | 2227-64-7 | 25g | 1247元 |
2025/05/22 | B2855 | 2-溴-3'-硝基苯乙酮 2-Bromo-3'-nitroacetophenone | 2227-64-7 | 5G | 60元 |