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23313-12-4

中文名称 L-抗坏血酸-2-单磷酸酯三环己铵盐
英文名称 L-ASCORBIC ACID 2-MONOPHOSPHATE TRI-CYCLOHEXYLAMMONIUM SALT
CAS 23313-12-4
分子式 C6H9O9P
分子量 256.1
MOL 文件 23313-12-4.mol
更新日期 2024/09/11 09:48:54
23313-12-4 结构式 23313-12-4 结构式

基本信息

中文别名
L-抗坏血酸-2-单磷酸酯三环己铵盐
维生素C磷酸酯(L-抗坏血酸-2-磷酸酯)
英文别名
Vitamin C phosphate
Ascorbyl-2-phosphate
ascorbate-2-phosphate
Ascorbyl monophosphate
Ascorbic Acid Impurity 6
Ascorbyl-2-monophosphate
2-Phospho-L-ascorbic acid
MIJPAVRNWPDMOR-ZAFYKAAXSA-N
L-Ascorbic acid, 2-(dihydrogen phosphate)
l-ascorbic acid 2-monophosphate tris-cyclohexylammonium salt
所属类别
医药中间体:原料药中间体

物理化学性质

沸点682.7±65.0 °C(Predicted)
密度2.01±0.1 g/cm3(Predicted)
酸度系数(pKa)1.38±0.10(Predicted)
形态Solid
颜色Off-white to light yellow

常见问题列表

生物活性
L-ascorbic acid 2-phosphate 是一种长效的维生素 C 衍生物 (vitamin C derivative),可以刺激胶原蛋白的表达和形成。L-ascorbic acid 2-phosphate 可以作为培养基补充人脂肪干细胞 (hASCs) 的成骨分化。L-ascorbic acid 2-phosphate 增加成骨细胞分化过程中 hASC 中的碱性磷酸酶 (ALP) 活性和 runx2A 的表达。
靶点

IC50: alkaline phosphatase (ALP); collagen formation; runx2A

体外研究

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc)  achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect . L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex.

Cell Proliferation Assay

Cell Line: Human corneal endothelial cells (HCECs)
Concentration: 0.1 mM; 0.3 mM; 1.5 mM
Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days
Result: Stimulated HCEC cells growth.
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