24144-92-1

中文名称 2,3',4,5'-四甲氧基二苯乙烯

英文名称 TMS

CAS 24144-92-1

分子式 C18H20O4

分子量 300.35

MOL 文件 24144-92-1.mol

24144-92-1 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

化合物TMS
5'-四甲氧基二苯乙烯
2,3',4,5'-四甲氧基二苯乙烯

英文别名

CS-961
SMB 00388
TMS, >=98%
5'-tetramethoxystilbene
3,5,2’,4’-Tetramethoxystilbene
2,3',4,5'-TETRAMETHOXYSTILBENE
(E)-2,3',4,5'-TETRAMETHOXYSTILBENE
TMS - Trans-2,3',4,5'-tetramethoxystilbene
(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE

所属类别

化学试剂：烯烃（环状与无环状）

物理化学性质

熔点78-79 °C

沸点459.9±40.0 °C(Predicted)

密度1.117±0.06 g/cm3(Predicted)

储存条件Sealed in dry,Store in freezer, under -20°C

溶解度DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml

形态粉末

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302

防范说明P280-P305+P351+P338

常见问题列表

生物活性

TMS ((E)-2,3',4,5'-tetramethoxystilbene) 是一种选择性和竞争性 CYP1B1 抑制剂，IC50 为 6 nM，Ki 值为 3 nM。TMS 对 CYP1A1 (IC50=300 nM) 和 CYP1A2 (IC50=3.1 μM) 的抑制作用较小。TMS 是白藜芦醇的甲基化衍生物，具有抗癌活性。

靶点

CYP1B1

6 nM (IC ₅₀ )

CYP1B1

3 nM (Ki)

CYP1A1

300 nM (IC ₅₀ )

CYP1A2

3.1 μM (IC ₅₀ )

体外研究

TMS, an analogue of resveratrol, is considered to be a potential cancer preventive agent since it is a potent inhibitor of CYP1B1. To assess survival of MCF-7 cells exposed to 1 μM benzo[a]pyrene (BP), 1 μM BP+1 μM TMS and 1 μM BP+4 μM TMS, cells ae incubated for up to 72 h without a media change. Luminescence units from exposed cells, expressed as a percentage of luminescence units from solvent (DMSO)-treated cells at the same time intervals. In all exposure groups, cell viability remains >90% for the first 24 h, but by 72 h, cell survival drops to 60-70%.

体内研究

To determine the contribution of CYP1B1 in development of hypertension in spontaneously hypertensive rats (SHR), the effect of TMS is examined on in SHR and WKY rats. Systolic BP steadily increases in SHR from 4 weeks of age. Starting from 8 weeks of age, daily injections of TMS reduce systolic BP in SHR to levels observed at the beginning of the experiment (207±7 vs. 129±2 mmHg). Systolic BP is not altered in WKY injected with TMS or its vehicle (129±7 vs. 127±4 mmHg) .