| Identification | Back Directory | [Name]
TMS | [CAS]
24144-92-1 | [Synonyms]
CS-961
SMB 00388
TMS, >=98%
5'-tetramethoxystilbene
3,5,2’,4’-Tetramethoxystilbene
2,3',4,5'-TETRAMETHOXYSTILBENE
(E)-2,3',4,5'-TETRAMETHOXYSTILBENE
TMS - Trans-2,3',4,5'-tetramethoxystilbene
(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE
1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE
Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy- | [Molecular Formula]
C18H20O4 | [MDL Number]
MFCD03428621 | [MOL File]
24144-92-1.mol | [Molecular Weight]
300.35 |
| Chemical Properties | Back Directory | [Melting point ]
78-79 °C | [Boiling point ]
459.9±40.0 °C(Predicted) | [density ]
1.117±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml | [form ]
Powder |
| Hazard Information | Back Directory | [Uses]
2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells. | [Uses]
CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml. | [Definition]
ChEBI:1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid. | [Biological Activity]
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro . | [storage]
Store at RT |
|
|