24268-41-5
24268-41-5 结构式
基本信息
莪术环二烯酮
莪术呋喃二烯酮
莪术呋喃二烯酮对照品
莪术呋喃二烯酮标准品
呋喃二烯酮,蓬莪术环二烯酮
Furanodienone
(1E,4E)-8,12-Epoxygermacra-1(10),4,7,11-tetraen-6-one
(5Z)-3,6,10-trimethyl-8,11-dihydrocyclodeca[b]furan-4(7H)-one
(5E,9E)-8,11-Dihydro-3,6,10-trimethylcyclodeca[b]furan-4(7H)-one
Cyclodeca[b]furan-4(7H)-one, 8,11-dihydro-3,6,10-trimethyl-, (5E,9E)-
物理化学性质
常见问题列表
Furanodienone (0-573.8 μM; 24 hours) exhibits IC 50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively. Furanodienone (0-150 μM; 24 hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells. Furanodienone (0-150 μM; 24 hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%.
Western Blot Analysis
| Cell Line: | RKO and HT-29 cells |
| Concentration: | 0 μM; 50 μM; 100 μM; 150 μM |
| Incubation Time: | 24 hours |
| Result: | Increased caspase-9 and -3. |
Apoptosis Analysis
| Cell Line: | RKO and HT-29 cells |
| Concentration: | 0 μM; 75 μM; 150 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis of colorectal cells (RKO and HT-29). |