2457-80-9
中文名称
5-脱氧-5-甲硫腺苷
英文名称
5'-DEOXY-5'-METHYLTHIOADENOSINE
CAS
2457-80-9
分子式
C11H15N5O3S
分子量
297.33
MOL 文件
2457-80-9.mol
更新日期
2025/04/27 10:03:01
2457-80-9 结构式
基本信息
中文别名
甲硫腺苷甲硫腺苷对照品
5'-甲硫腺苷
5′-脱氧-5′-腺苷
5-脱氧-5-甲硫腺苷
5ˊ-脱氧-5ˊ-甲硫基腺苷
5'-脱氧-5'-硫代甲基酰苷
5'-S-甲基-5'-硫代腺苷
甲硫腺苷:5-脱氧-5-甲硫腺苷
5-脱氧-5-甲硫腺苷 (5'-脱氧-5'-硫代甲基酰苷、5ˊ-脱氧-5ˊ-甲硫基腺苷)
英文别名
MTAMESADO
SKL060
2457-80-9
NSC 335422
vitaminl(sub2)
1-(6-AMino-9H-purin
Methylthioadenosine
5’-methylthioadenosine
Adenylthiomethylpentose
所属类别
生物化工：脱氧核苷酸及其类似物物理化学性质
熔点210-213 °C (dec.)
沸点642.7±65.0 °C(Predicted)
密度1.85±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度DMF（少量）、DMSO（少量）、甲醇（少量）
酸度系数(pKa)13.10±0.70(Predicted)
形态白色固体
颜色白色至灰白色
生物来源synthetic (organic)
BRN42420
常见问题列表
简介
5-脱氧-5-甲硫腺苷是一种C-5' 的羟基被甲硫基（甲硫基）取代的腺苷，可用作抑制剂。生物活性
5'-Methylthioadenosine 是由 S-腺苷酸产生的，有强效的抑制作用。靶点
|
Human Endogenous Metabolite
|
体外研究
5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration [1] .