245747-71-1
245747-71-1 结构式
基本信息
NFAT转录因子调节剂-1
NFAT Transcription Factor Regulator-1
4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-112778 | NFAT Transcription Factor Regulator-1 | 245747-71-1 | 1 mg | 395元 |
| 2025/02/08 | HY-112778 | 245747-71-1 NFAT Transcription Factor Regulator-1 | 245747-71-1 | 10mM * 1mLin DMSO | 983元 |
| 2025/02/08 | HY-112778 | 245747-71-1 NFAT Transcription Factor Regulator-1 | 245747-71-1 | 5mg | 1073元 |
常见问题列表
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IL-2 182 nM (IC 50 ) |
NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC 50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC 50 s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release.
NFAT Transcription Factor Regulator-1 is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys in vivo for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator-1 has potential similar to that of cyclosporine for use in transplantation.