249537-73-3
中文名称
NFAT INHIBITOR
英文名称
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
CAS
249537-73-3
分子式
C75H118N20O22S
分子量
1683.93
MOL 文件
249537-73-3.mol
更新日期
2024/05/05 20:58:13
249537-73-3 结构式
基本信息
中文别名
化合物AGI-519811R-VIVIT游离态
NFAT INHIBITOR-1
细胞渗透性肽抑制剂多肽H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
L-蛋氨酰-L-丙氨酰甘氨酰-L-脯氨酰-L-组氨酰-L-脯氨酰-L-缬氨酰-L-异亮氨酰-L-缬氨酰-L-异亮氨酰-L-苏氨酰甘氨酰-L-脯氨酰-L-组氨酰-L-ALPHA-谷氨酰-L-谷氨酸
英文别名
VIVITNFAT INHIBITOR
MAGPHPVIVITGPHEE
NFAT INHIBITOR?, >98%
NFAT Inhibitor (VIVIT peptide)
NFAT Inhibitor >96% (HPLC), solid
NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%
MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点1982.4±65.0 °C(Predicted)
密度1.334±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度DMSO: 15 mg/ml; Water: 10 mg/ml
酸度系数(pKa)3.12±0.10(Predicted)
形态solid
水溶解性Soluble to 2 mg/ml in water
序列H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
NFAT INHIBITOR价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-P1026 | NFAT INHIBITOR NFAT Inhibitor | 249537-73-3 | 5mg | 2800元 |
| 2024/04/30 | HY-P1026 | NFAT INHIBITOR NFAT Inhibitor | 249537-73-3 | 10mg | 5100元 |
| 2024/04/30 | HY-P1026 | NFAT INHIBITOR NFAT Inhibitor | 249537-73-3 | 25mg | 9900元 |
常见问题列表
生物活性
NFAT Inhibitor (VIVIT peptide) 是一种 NFAT 的细胞渗透性肽抑制剂，可选择性抑制钙调磷酸酶介导的 NFAT 脱磷酸作用。靶点
Nuclear factor of activated Tcells (NFAT)
体外研究
NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.
Western Blot Analysis
| Cell Line: | Human peripheral blood CD14 + monocytes |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours or 21 days |
| Result: | Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9. |