249537-73-3

中文名称 NFAT INHIBITOR

英文名称 H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

CAS 249537-73-3

分子式 C75H118N20O22S

分子量 1683.93

MOL 文件 249537-73-3.mol

更新日期 2025/05/05 22:26:24

249537-73-3 结构式

基本信息物理化学性质安全数据图谱信息 NFAT INHIBITOR价格(试剂级) 常见问题列表

基本信息

中文别名

化合物AGI-5198
11R-VIVIT游离态
NFAT INHIBITOR-1
细胞渗透性肽抑制剂多肽H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
L-蛋氨酰-L-丙氨酰甘氨酰-L-脯氨酰-L-组氨酰-L-脯氨酰-L-缬氨酰-L-异亮氨酰-L-缬氨酰-L-异亮氨酰-L-苏氨酰甘氨酰-L-脯氨酰-L-组氨酰-L-ALPHA-谷氨酰-L-谷氨酸

英文别名

VIVIT
NFAT INHIBITOR
MAGPHPVIVITGPHEE
NFAT INHIBITOR?, >98%
NFAT Inhibitor (VIVIT peptide)
NFAT Inhibitor >96% (HPLC), solid
NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%
MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点1982.4±65.0 °C(Predicted)

密度1.334±0.06 g/cm3(Predicted)

储存条件-20°C

溶解度DMSO: 15 mg/ml; Water: 10 mg/ml

酸度系数(pKa)3.12±0.10(Predicted)

形态solid

颜色White to off-white

水溶解性Soluble to 2 mg/ml in water

序列H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338

安全说明22-24/25

WGK Germany3

海关编码2933299090

图谱信息

NFAT INHIBITOR(249537-73-3)质谱(MS)

NFAT INHIBITOR价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/02/08	HY-P1026	NFAT INHIBITOR NFAT Inhibitor	249537-73-3	1mg	700元
2025/02/08	HY-P1026	NFAT INHIBITOR NFAT Inhibitor	249537-73-3	5mg	2800元
2025/02/08	HY-P1026	NFAT INHIBITOR NFAT Inhibitor	249537-73-3	10mg	5100元

常见问题列表

生物活性

NFAT Inhibitor (VIVIT peptide) 是一种 NFAT 的细胞渗透性肽抑制剂，可选择性抑制钙调磷酸酶介导的 NFAT 脱磷酸作用。

靶点

Nuclear factor of activated Tcells (NFAT)

体外研究

NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.

Western Blot Analysis

Cell Line:	Human peripheral blood CD14 ⁺ monocytes
Concentration:	10 μM
Incubation Time:	24 hours or 21 days
Result:	Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.