2666951-70-6
中文名称
(2S,4R)-N-((S)-3-(4-((4-((反式-3-(3-氯-4-氰基苯氧基)-2,2,4,4-四甲基环丁基)氨基甲酰基)苯基)乙炔基)哌啶-1-基)-3-氧代-1-苯基丙基)-4-羟基-1-((R)-3-甲基-2-(3-甲基异恶唑-5-基)丁酰基)吡咯烷-2-甲酰胺
英文名称
2-Pyrrolidinecarboxamide, N-[(1S)-3-[4-[2-[4-[[[trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]ethynyl]-1-piperidinyl]-3-oxo-1-phenylpropyl]-4-hydroxy-1-[(2R)-3-methyl-2-(3-methyl-5-isoxazolyl)-1-oxobutyl]-, (2S,4R)-
CAS
2666951-70-6
分子式
C52H59ClN6O7
分子量
915.51
MOL 文件
2666951-70-6.mol
更新日期
2025/06/08 17:22:41
2666951-70-6 结构式
基本信息
中文别名
(2S,4R)-N-((S)-3-(4-((4-((反式-3-(3-氯-4-氰基苯氧基)-2,2,4,4-四甲基环丁基)氨基甲酰基)苯基)乙炔基)哌啶-1-基)-3-氧代-1-苯基丙基)-4-羟基-1-((R)-3-甲基-2-(3-甲基异恶唑-5-基)丁酰基)吡咯烷-2-甲酰胺 英文别名
2-Pyrrolidinecarboxamide, N-[(1S)-3-[4-[2-[4-[[[trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]ethynyl]-1-piperidinyl]-3-oxo-1-phenylpropyl]-4-hydroxy-1-[(2R)-3-methyl-2-(3-methyl-5-isoxazolyl)-1-oxobutyl]-, (2S,4R)-物理化学性质
沸点1095.6±65.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
酸度系数(pKa)13.75±0.70(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
ARD-266 is a potent PROTAC Degrader (DC50 = 0.2 ~1 nM, IC50 = 1~6 nM). ARD-266 effectively induces degradation of AR protein in AR-positive (AR+) LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2?1 nM. ARD-266 is capable of reducing the AR protein level by >95% in these AR+ prostate cancer cell lines and effectively reduces ARregulated gene expression suppression.