2746-81-8

中文名称氟奋乃静庚酸酯

英文名称 fluphenazine O-enantate

CAS 2746-81-8

分子式 C29H38F3N3O2S

分子量 549.698

MOL 文件 2746-81-8.mol

2746-81-8 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

氟奋乃静庚酸酯
癸氟奋乃静杂质C(EP)
氟奋乃静庚酸盐 EP标准品
氟奋乃静癸酸酯杂质C (EP)
癸氟奋乃静杂质3(癸氟奋乃静EP杂质C)

英文别名

moditen enanthate
fluphenazine O-enantate
Fluphenazine enantate CRS
Fluphenazine Decanoate Impurity 3 (Fluphenazine Decanoate EP Impurity C)
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate
2-[4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl heptanoate
enanthic acid 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl ester
Heptanoic acid, 2-4-3-2-(trifluoromethyl)-10H-phenothiazin-10-ylpropyl-1-piperazinylethyl ester

所属类别

化学试剂：肼

物理化学性质

熔点184.5°C

沸点629.4±55.0 °C(Predicted)

密度1.1661 (estimate)

储存条件2-8°C

溶解度Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.

酸度系数(pKa)7.32±0.10(Predicted)

形态neat

主要应用pharmaceutical (small molecule)

InChIKeyLRWSFOSWNAQHHW-UHFFFAOYSA-N

SMILESFC(F)(F)c1cc2c(cc1)Sc3c(cccc3)N2CCCN4CCN(CC4)CCOC(=O)CCCCCC

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS06,GHS08

警示词危险

危险性描述H301-H360

防范说明P201-P301+P310+P330

危险品运输编号3249

WGK GermanyWGK 3

危险等级6.1(b)

包装类别III

存储类别6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

危险性类别Acute Tox. 3 Oral
Repr. 1A

常见问题列表

生物活性

Fluphenazine enanthate 是第一种长效抗精神病药物，用于研究精神分裂症。

体内研究

Fluphenazine enanthate (2,4, 8 mg/kg; IM) significant inhibition of the avoidance performance is observed as long as 16, 23, and 28 days, respectively.
Fluphenazine enanthate (8 mg/kg) drinking behavior is almost completely suppressed for 24 hours immediately following the administration.
Fluphenazine enanthate (8 mg/kg) produces transient body weight Iosses in the rats.

Animal Model:	Fifty-four male adult rats of Wistar strain
Dosage:	2, 4, and 8 mg/kg
Administration:	Index medicus (IM )
Result:	Three doses of Fluphenazine enanthate significant inhibition of the avoidance performance was observed as long as 16, 23, and 28 days, respectively.