2765218-56-0
中文名称
5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE
英文名称
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-
CAS
2765218-56-0
分子式
C16H15N3O2S
分子量
313.37
MOL 文件
2765218-56-0.mol
更新日期
2025/11/12 10:12:01
2765218-56-0 结构式
基本信息
中文别名
5-苯基-N-[3-(2-噻唑基)丙基]异噁唑-3-甲酰胺5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE
英文别名
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-物理化学性质
沸点559.1±45.0 °C(Predicted)
密度1.266±0.06 g/cm3(Predicted)
储存条件-10 to -25°C
溶解度DMSO: 2mg/mL, clear
酸度系数(pKa)13.06±0.46(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
PY-60 is a novel activator of YAP, promoting expansion of epidermal keratinocytes ex vivo and in vivo, targeting ANXA2 to activate YAP, activating a robust, YAP- dependent transcriptional program in multiple cell types. Chemical proteomics revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates with YAP at the cell membrane in response to increased cell density. PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP.