28289-54-5

熔点aprox. 36°C

沸点128-132 °C12 mm Hg(lit.)

密度1.001±0.06 g/cm3(Predicted)

储存条件-20°C冷冻

溶解度Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)

酸度系数(pKa)8.66±0.40(Predicted)

形态Solid

颜色Pale Yellow to Light Yellow

Merck13,6319

稳定性稳定的。与强氧化剂不相容。

警示词危险

危险品运输编号UN 2811 6.1/PG 2

WGK Germany3

RTECS号UT8358900

危险等级6.1(b)

包装类别III

毒性Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.