| Identification | Back Directory | [Name]
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE | [CAS]
28289-54-5 | [Synonyms]
MPTP
NSC 139654
1-METHYL-4-PHENYL-PIPERIDINE-3-EN
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin
1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin
1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE
N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-
1-METHYL-4-PHENYL-1,2,3,6-TETRA-*HYDROPY RIDINE FREE
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)ochloride
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base | [EINECS(EC#)]
248-939-7 | [Molecular Formula]
C12H15N | [MDL Number]
MFCD00006120 | [MOL File]
28289-54-5.mol | [Molecular Weight]
173.25 |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow Solid | [Melting point ]
aprox. 36°C | [Boiling point ]
128-132 °C12 mm Hg(lit.)
| [density ]
1.001±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
8.66±0.40(Predicted) | [color ]
Pale Yellow to Light Yellow | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Merck ]
13,6319 |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Solid | [Uses]
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys. | [Definition]
ChEBI: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4. | [Metabolic pathway]
N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
in a rat pheochromocytoma cell line is oxidized to give
the N-methyl-4-phenylpyridinium ion. |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS08,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H370-H301 | [Precautionary statements ]
P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501 | [Hazard Codes ]
T | [Risk Statements ]
25-39/23/24/25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
UT8358900
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Hazardous Substances Data]
28289-54-5(Hazardous Substances Data) | [Toxicity]
Human toxicity
originally discovered when it was an unexpected by-product
from the illicit synthesis of a heroin substitute (i.e., meperidine
analog). Currently used experimentally as the primary animal
model for the study of Parkinson’s disease. MPTP is a neurotoxicant
that is activated to 1-methyl-4-phenylpyridinium ion
(MPP1) by the actions of monoamine oxidase B located in the
mitochondria of brain astrocytes. The MPP1 is then transported
into dopamine, and to a lesser extent, other monoaminergic
neurons. Once inside these dopamine neurons in the
substantia nigra, it destroys these neurons by mechanisms that
may involve an oxidative cascade and/or inhibition of electron
transport. Intoxication causes a parkinsonism syndrome almost
identical in signs and symptoms to Parkinson’s disease, including
rigidity, bradykinesia, tremor, and postural instability. In
the event of known ingestion, immediate (but not delayed)
administration of a monoamine oxidase inhibitor (especially
one selective for MAO-B like deprenyl) and dopamine uptake
inhibitor can be therapeutic. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Rhawn Reagent
|
| Telephone: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|