283167-06-6
中文名称
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide
英文名称
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide
CAS
283167-06-6
分子式
C14H17FN2O2
分子量
264.3
MOL 文件
283167-06-6.mol
更新日期
2025/05/13 19:27:05
283167-06-6 结构式
基本信息
中文别名
化合物FK962N-(1-乙酰基哌啶-4-基)-4-氟苯甲酰胺
英文别名
FK962N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide
Benzamide, N-(1-acetyl-4-piperidinyl)-4-fluoro-
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-133025 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide FK962 | 283167-06-6 | 1 mg | 310元 |
| 2025/02/08 | HY-133025 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide FK962 | 283167-06-6 | 5mg | 748元 |
| 2025/02/08 | HY-133025 | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide FK962 | 283167-06-6 | 10mg | 1185元 |
常见问题列表
生物活性
FK962 是生长抑素 (somatostatin) 释放的增强剂，具有认知增强作用。靶点
Somatostatin release
体外研究
FK962 (1 nM-1 μM) significantly enhances high K + -evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca 2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.
体内研究
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease.
| Animal Model: | Male Lister Hooded rats, weighing approximately 270-300 |
| Dosage: | 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg |
| Administration: | Administered i.p. |
| Result: | Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |