286852-20-8
中文名称
Cyclosporin A-Derivative 1 Free base
英文名称
Cyclosporin A-Derivative 1 Free base
CAS
286852-20-8
分子式
C65H117N11O14
分子量
1276.69
MOL 文件
286852-20-8.mol
286852-20-8 结构式
基本信息
英文别名
Cyclosporin A-Derivative 1 Free baseN-Methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-
物理化学性质
沸点1225.9±65.0 °C(Predicted)
密度1.093±0.06 g/cm3(Predicted)
溶解度DCM, Methanol
酸度系数(pKa)13.07±0.46(Predicted)
形态Solid
颜色Off-White
序列Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar}
Cyclosporin A-Derivative 1 Free base价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-P1355A | Cyclosporin A-Derivative 1 Free base Cyclosporin A-Derivative 1 Free base | 286852-20-8 | 1mg | 1500元 |
| 2026/09/15 | HY-P1355A | Cyclosporin A-Derivative 1 Free base Cyclosporin A-Derivative 1 Free base | 286852-20-8 | 5mg | 3500元 |
| 2026/09/15 | HY-P1355A | Cyclosporin A-Derivative 1 Free base Cyclosporin A-Derivative 1 Free base | 286852-20-8 | 10 mg | 5425元 |
常见问题列表
生物活性
Cyclosporin A-Derivative 1 (Free base) 是环孢菌素 A 衍生的结晶中间体，来自专利 WO 2013167703 A1。Cyclosporin A 是一种免疫抑制剂，能够与亲环蛋白结合并抑制钙调磷酸酶。体外研究
Cyclosporin A-Derivative 1 is a non-immunosuppressive Cyclosporin A derivative. The cyclosporin is acylated on the butenyl-methyl-threonine side chain and then subjected to a ring-opening reaction (the ring opens between the sarcosine and the N-methyl-leucine residues). Cyclosporin A-Derivative 1 is a linear peptide intermediate.