300-84-5
300-84-5 结构式
基本信息
亚牛磺酸
2-AMINOETHANESULFUNIC ACID
2-AMINOETHYLSULFINIC ACID
HYPOTAURINE
hypotaurine crystalline
Ethanesulfinic acid, 2-amino-
物理化学性质
安全数据
常见问题列表
亚牛磺酸是牛磺酸的前体之一，经过氧化变为牛磺酸，哺乳动物主要通过这条途径合成，而合成牛磺酸的氧化酶是一个非限速的，所以可以保持一个平衡。晶体的溶解度只有6－7％，亚牛磺酸钠要高一些。
自1975年Hayes等报道，缺乏牛磺酸会导致幼猫视功能减退甚至失明后，人们对牛磺酸的营养作用越来越关注。
先在发现的牛磺酸功能很多，但主要是促进细胞膜对糖的吸收，此外还可作用于胰岛素受体，发挥胰岛素样效应。
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Human Endogenous Metabolite
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Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion.
Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord.