317326-90-2
317326-90-2 结构式
基本信息
中文别名
化合物 T27546 英文别名
HL98CHLI 98C
HLI 98C
HL98C
10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione
应用领域
用途一
HLI98C is a HDM2 ubiquitin ligase inhibitor. HLI98C exhibits cytotoxic activities and HDM2 E3 ligase inhibitory activities. In cells, HLI98C allows the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis. The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53 for degradation. HLI98C may demonstrate anti-tumor activity by inhibiting recognition of the E3 enzyme and substrate.