| Identification | Back Directory | [Name]
HLI 98C | [CAS]
317326-90-2 | [Synonyms]
HL98C
HLI 98C
HLI 98C; HL98C
10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione | [Molecular Formula]
C17H9ClN4O4 | [MDL Number]
MFCD01630070 | [MOL File]
317326-90-2.mol | [Molecular Weight]
368.73 |
| Hazard Information | Back Directory | [Description]
HLI98C is a HDM2 ubiquitin ligase inhibitor. HLI98C exhibits cytotoxic activities and HDM2 E3 ligase inhibitory activities. In cells, HLI98C allows the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis. The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53 for degradation. HLI98C may demonstrate anti-tumor activity by inhibiting recognition of the E3 enzyme and substrate. | [Uses]
HLI98C is a ubiquitin ligase inhibitor. HLI98C inhibits p53 ubiquitylation. HLI98C inhibits HDM2 auto-ubiquitylation[1]. | [References]
[1] Yang Y, et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell. 2005 Jun;7(6):547-59. DOI:10.1016/j.ccr.2005.04.029 |
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