325850-81-5

中文名称 GRI977143; GRI-977143

英文名称 2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid

CAS 325850-81-5

分子式 C22H17NO4S

分子量 391.44

MOL 文件 325850-81-5.mol

更新日期 2026/01/19 10:59:08

325850-81-5 结构式

基本信息物理化学性质安全数据图谱信息 GRI977143; GRI-977143价格(试剂级) 常见问题列表

基本信息

中文别名

2-[3-(1,3-二氧代-1H,3H-苯并[DE]异喹啉-2-基)-丙基磺酰基]-苯甲酸

英文别名

GRI977143
GRI977143
GRI-977143
2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-benzoic acid
2-((3-(1,3-Dioxo-(1H)benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic Acid
Benzoic acid, 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-
2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid

物理化学性质

储存条件2-8°C

溶解度DMSO：可溶10mg/mL，澄清

形态粉末

颜色白色至浅棕色

InChI1S/C22H17NO4S/c24-20-16-9-3-6-14-7-4-10-17(19(14)16)21(25)23(20)12-5-13-28-18-11-2-1-8-15(18)22(26)27/h1-4,6-11H,5,12-13H2,(H,26,27)

InChIKeyGMVZUCHUOYUMLL-UHFFFAOYSA-N

SMILESS(CCC[n]2[c](c3c4c([c]2=O)cccc4ccc3)=O)c1c(cccc1)C(=O)O

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07,GHS09

警示词警告

危险性描述H302-H410

防范说明P264-P270-P273-P301+P312-P391-P501

危险品标志Xn,N

危险类别码22-43-50/53

安全说明36/37-60-61

危险品运输编号UN 3077 9 / PGIII

WGK Germany3

存储类别11 - Combustible Solids

危险性类别Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1

图谱信息

GRI977143; GRI-977143(325850-81-5)核磁图(¹HNMR)

GRI977143; GRI-977143价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-100676	GRI977143; GRI-977143 GRI977143	325850-81-5	1 mg	556元
2025/12/22	HY-100676	GRI977143; GRI-977143 GRI977143	325850-81-5	10 mM * 1 mLin DMSO	1071元
2025/12/22	HY-100676	GRI977143; GRI-977143 GRI977143	325850-81-5	5 mg	1244元

常见问题列表

生物活性

GRI977143 是特异性的 LPA2 受体的激动剂，其EC50 值为3.3 μM。

靶点

LPA ₂ Receptor

3.3 μM (EC ₅₀ )

体外研究

GRI977143 (10 μM, 24-72 h) is effective in reducing activation of caspases 3, 7, 8, and 9 and inhibits poly(ADP-ribose)polymerase 1 cleavage and DNA fragmentation in different extrinsic and intrinsic models of apoptosis.
GRI977143 is an effective stimulator of extracellular signal-regulated kinase 1/2 activation and promotes the assembly of a macromolecular signaling complex consisting of LPA2, Na+-H+ exchange regulatory factor 2, and thyroid receptor interacting protein 6.

Cell Proliferation Assay

Cell Line:	Vector- and LPA2-transduced MEF cells (2 × 10 ⁴ ) ^[1] .
Concentration:	10 μM.
Incubation Time:	24-72 h.
Result:	Did not cause a significant increase in vector cell proliferation except at 72 h (p < 0.05).

Apoptosis Analysis.

Cell Line:	Doxorubicin-induced apoptotic signaling in vector-transduced or LPA2-transduced MEF.
Concentration:	10 μM.
Incubation Time:	24 h.
Result:	Reduced caspase 3 and 7 activation on LPA2-transduced MEF cells by 51 ± 3% and was approximately as potent as 3 μM LPA or OTP. Protected against doxorubicin-induced apoptosis by inhibiting caspase 3, 7, 8, and 9 and reducing DNA fragmentation.