328069-91-6

中文名称化合物 MT477

英文名称 MT477

CAS 328069-91-6

分子式 C31H30N2O12S3

分子量 718.77

MOL 文件 328069-91-6.mol

328069-91-6 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 MT477

英文别名

MT477
tetramethyl 6'-[(2,5-dioxopyrrolidin-1-yl)acetyl]-7'-methoxy-5',5'-dimethyl-5',6'-dihydrospiro[1,3-dithiole-2,1'-thiopyrano[2,3-c]quinoline]-2',3',4,5-tetracarboxylate

物理化学性质

沸点916.0±65.0 °C(Predicted)

密度1.55±0.1 g/cm3(Predicted)

酸度系数(pKa)-6.45±0.70(Predicted)

应用领域

用途一

MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays.