32886-15-0

中文名称 Neoenactin M1

英文名称 Neoenactin M1

CAS 32886-15-0

分子式 C19H36N2O5

分子量 372.502

MOL 文件 32886-15-0.mol

32886-15-0 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T24412
化合物 LIPOXAMYCIN

英文别名

G-26146
Brn 2394950
Neoenactin M1
L-2-Amino-N-(14-methyl-3,10-dioxopentadecyl)hydracrylohydroxamic acid
(2S)-2-Amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)propanamide
Hydracrylohydroxamic acid, 2-amino-N-(14-methyl-3,10-dioxopentadecyl)-, L-
Propanamide, 2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)-, (S)-
Propanamide, 2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)-, (2S)-

物理化学性质

沸点578.1±60.0 °C(Predicted)

密度1.094±0.06 g/cm3(Predicted)

酸度系数(pKa)8.46±0.50(Predicted)

常见问题列表

生物活性

Lipoxamycin 是一种抗真菌抗生素，也是一种有效的丝氨酸棕榈酰转移酶 (serine palmitoyltransferase) 抑制剂，IC50 为 21 nM。

靶点

Serine palmitoyltransferase

体外研究

Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida . Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays.
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme.

体内研究

Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells.