| Identification | Back Directory | [Name]
Neoenactin M1 | [CAS]
32886-15-0 | [Synonyms]
G-26146
Brn 2394950
Neoenactin M1
L-2-Amino-N-(14-methyl-3,10-dioxopentadecyl)hydracrylohydroxamic acid
(2S)-2-Amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)propanamide
Hydracrylohydroxamic acid, 2-amino-N-(14-methyl-3,10-dioxopentadecyl)-, L-
Propanamide, 2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)-, (S)- | [Molecular Formula]
C19H36N2O5 | [MDL Number]
MFCD01722759 | [MOL File]
32886-15-0.mol | [Molecular Weight]
372.502 |
| Hazard Information | Back Directory | [Uses]
Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2]. | [in vivo]
Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells[1]. | [References]
[1] S M Mandala, et al. Inhibition of Serine Palmitoyl-Transferase Activity by Lipoxamycin. J Antibiot (Tokyo). 1994 Mar;47(3):376-9. DOI:10.7164/antibiotics.47.376
[2] H A Whaley. The Structure of Lipoxamycin, a Novel Antifungal Antibiotic. J Am Chem Soc. 1971 Jul 28;93(15):3767-9. DOI:10.1021/ja00744a036 |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|