3374-88-7
中文名称
ICA
英文名称
ICA
CAS
3374-88-7
分子式
C13H10N4S
分子量
254.31
MOL 文件
3374-88-7.mol
更新日期
2024/04/26 20:46:00
3374-88-7 结构式
基本信息
英文别名
N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine2-Pyridinamine, N-[4-(2-pyridinyl)-2-thiazolyl]-
常见问题列表
生物活性
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) 是SK通道 (SK channel) 抑制剂。ICA有抗利什曼原虫活性，IC50 值为2.1 µM。靶点
IC50: 2.1 µM (Antileishmanial)
体外研究
The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters.