| Identification | Back Directory | [Name]
ICA | [CAS]
3374-88-7 | [Synonyms]
N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine
2-Pyridinamine, N-[4-(2-pyridinyl)-2-thiazolyl]- | [Molecular Formula]
C13H10N4S | [MOL File]
3374-88-7.mol | [Molecular Weight]
254.31 |
| Chemical Properties | Back Directory | [Boiling point ]
466.4±48.0 °C(Predicted) | [density ]
1.339±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 49.5 mg/mL (194.64 mM) | [form ]
Solid | [pka]
3.20±0.10(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 μM. | [References]
[1] Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. DOI:10.1016/j.ejmech.2015.08.013
[2] Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76. DOI:10.1097/FJC.0000000000000259 |
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ChemeGen
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18818260767 |
| Website: |
https://www.chemegen.com |
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