34429-70-4
34429-70-4 结构式
基本信息
中文别名
替达霉素A 英文别名
TIRANDAMYCINtirandamycin A
3-[(1E,2E,4E,6R)-1-Hydroxy-4-methyl-6-[(1S,4α,6S)-1,2α,7α-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8β-yl]-2,4-heptadien-1-ylidene]-2,4-pyrrolidinedione
常见问题列表
生物活性
Tirandamycin A, 一种抗生素， 是一种细菌 RNA 聚合酶 (bacterial RNA polymerase) 抑制剂。Tirandamycin A 具有抗阿米巴原虫和抗菌性能。体外研究
A 60 μM treatment with Tirandamycin A results in a slightly stronger inhibition, demonstrating a 84.2% reduction in growth of Entamoeba histolytica HM-1:IMSS and 64.8% reduction in growth by Entamoeba histolytica Col. Tirandamycin A inhibits chain initiation and elongation of bacterial RNA polymerase without acting on mammalian polymerases.