350997-39-6
中文名称
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
英文名称
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
CAS
350997-39-6
分子式
C9H6Cl2N2OS
分子量
261.13
MOL 文件
350997-39-6.mol
更新日期
2025/05/09 09:36:20
350997-39-6 结构式
基本信息
中文别名
3,4-二氯苯并[B]噻吩-2-甲酰肼 英文别名
OGG1-IN-08OGG1-IN-O8
O8 OGG1 Inhibitor
OGG1 Inhibitor O8
OGG1 Inhibitor O8 >=98% (HPLC)
3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
物理化学性质
密度1.587±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度DMF: 5mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
酸度系数(pKa)11.75±0.30(Predicted)
形态粉末
颜色白色至米色
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-112902 | OGG1-IN-08 | 350997-39-6 | 1 mg | 240元 |
| 2025/02/08 | HY-112902 | 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE OGG1-IN-08 | 350997-39-6 | 5mg | 600元 |
| 2025/02/08 | HY-112902 | 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE OGG1-IN-08 | 350997-39-6 | 10mM * 1mLin DMSO | 660元 |
常见问题列表
生物活性
OGG1-IN-08 是一种有效的 8-氧鸟嘌呤 DNA 糖基酶-1 (OGG1) 抑制剂，其 IC50 值为 0.22 μM。OGG1-IN-08 降低 OGG1 的糖基化酶和裂解酶活性。靶点
IC50: 0.22 μM (OGG1)
体外研究
OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively.OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control.OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor.