35286-59-0
中文名称
地榆皂苷Ⅱ
英文名称
Ziyuglycoside II
CAS
35286-59-0
分子式
C35H56O8
分子量
604.83
MOL 文件
35286-59-0.mol
更新日期
2024/06/13 15:04:45
35286-59-0 结构式
基本信息
中文别名
地榆甙II地榆皂苷LL
地榆皂苷 II
地榆皂苷II对照品,
地榆皂苷II、地榆苷Ⅱ
地榆皂苷II(标准品)
英文别名
Gouguside 1Ziyuglycoside
Ziyuglycoside II
Zigu-glucoside II
(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oicaci
(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, (3β)-
(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
所属类别
天然产物：萜类物理化学性质
外观性状白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于地榆。
熔点260-263℃
沸点716.2±60.0 °C(Predicted)
密度1.25
储存条件-20°C, protect from light
溶解度Soluble in DMSO and methanol;
酸度系数(pKa)4.47±0.70(Predicted)
形态粉末
水溶解性不溶于水
地榆皂苷Ⅱ价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 5mg | 550元 |
| 2024/04/30 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 10mg | 950元 |
常见问题列表
生物活性
Ziyuglycoside II 是从 Sanguisorba officinalis L. 中提取的三萜皂苷化合物。Ziyuglycoside II 诱导活性氧 (ROS) 产生和凋亡 (apoptosis)。 具有抗炎和抗癌作用。体外研究
Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC
50
of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively.
Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h.
Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells.
Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent.
Cell Viability Assay
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 10, 20, 30, 40, 50, 60 μM |
| Incubation Time: | 24 hours and 48 hours |
| Result: | The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. |
Cell Cycle Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | Induced G0/G1 and S phase arrest. |
Apoptosis Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | The apoptotic rate was significantly increased in comparison to that of the control. |
Western Blot Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | Treatment resulted in increased expressions of both p53 and p21. |