36840-10-5
中文名称
36840-10-5
英文名称
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)
CAS
36840-10-5
分子式
C20H16N2O6
分子量
380.35
MOL 文件
36840-10-5.mol
36840-10-5 结构式
基本信息
中文别名
化合物 T11875(2E,2E)-4,4-([1,1-二联苯]-4,4-叉基二(氨叉基))二(4-氧亚基丁-2-烯酸)
英文别名
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)4,4-(4,4-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)(WX610172)
2-Butenoic acid, 4,4'-([1,1'-biphenyl]-4,4'-diyldiimino)bis[4-oxo-
物理化学性质
沸点758.0±60.0 °C(Predicted)
密度1.444±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 83.33 mg/mL (219.09 mM)
酸度系数(pKa)3.16±0.10(Predicted)
形态Solid
颜色Light yellow to yellow
常见问题列表
生物活性
LPA2 antagonist 2 是一种选择性 LPA2 拮抗剂，IC50 为 28.3 nM，Ki 为 21.1 nM，比 LPA3 (IC50 为 13.85 μM) 选择性高 480 倍以上。靶点
IC50: 28.3 nM (LPA 2 ); 13.85 μM (LPA 3 )
体外研究
Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA 1 with an Imax of 59.0% at 30 µM.