| Identification | Back Directory | [Name]
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid) | [CAS]
36840-10-5 | [Synonyms]
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)
4,4-(4,4-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)(WX610172)
2-Butenoic acid, 4,4'-([1,1'-biphenyl]-4,4'-diyldiimino)bis[4-oxo- | [Molecular Formula]
C20H16N2O6 | [MDL Number]
MFCD00566434 | [MOL File]
36840-10-5.mol | [Molecular Weight]
380.35 |
| Chemical Properties | Back Directory | [Boiling point ]
758.0±60.0 °C(Predicted) | [density ]
1.444±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 83.33 mg/mL (219.09 mM) | [form ]
Solid | [pka]
3.16±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
LPA2 antagonist 2 (H2L 5226501) is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM)[1]. | [Biological Activity]
LPA2 antagonist 2 is a selective LPA2 antagonist with IC50 of 28.3 nM and Ki of 21.1 nM, >480-fold selectivity over LPA3 (IC50 of 13.85 μM). | [in vitro]
Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. | [target]
IC50: 28.3 nM (LPA 2 ); 13.85 μM (LPA 3 ) | [storage]
Store at -20°C | [References]
[1] Fells JI, et al. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg Med Chem. 2008 Jun 1;16(11):6207-17. DOI:10.1016/j.bmc.2008.04.035 |
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