常见问题列表
生物活性
M77976 是一种特异性的，ATP 竞争性的丙酮酸脱氢酶激酶 PDK4 抑制剂，其作用的 IC50 值为 648 μM。M77976 有用于肥胖症和糖尿病研究的潜力。靶点
IC50: 648 μM (PDK4)
体外研究
M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid.
M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4.