39718-89-3
39718-89-3 结构式
基本信息
中文别名
胺普芬阿米洛芬
阿明洛芬
2-(4-((2-甲基烯丙基)氨基)苯基)丙酸
英文别名
EB 382Minalfen
Minalfene
alminoprofen
Alminoprofene
Alminoprofeno
rac AlMinoprofen
alminoprofen USP/EP/BP
ALMINOPROFEN(FORR&DONLY)
Alminoprofene [inn-french]
物理化学性质
熔点107°
沸点360.1°C (rough estimate)
密度1.0697 (rough estimate)
折射率1.5100 (estimate)
酸度系数(pKa)4.86±0.50(Predicted)
常见问题列表
生物活性
Alminoprofen 是苯丙酸类非甾体抗炎药 (NSAID)。Alminoprofen 同时具有抑制分泌磷脂酶A2 (sPLA2) 活性和抗环氧化酶 (COX-2) 的活性。靶点
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sPLA2
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COX-2
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体外研究
Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both sPLA2 but also COX-2. Alminoprofen (from 0 to 50 μM) induces a dose-related inhibitory response on thelevels of PGE2 formed by the CRL-1517 cell line.
体内研究
Alminoprofen (100-300 mg/kg; p.o.) exerts an anti-inflammatory activity.
| Animal Model: | Groups of Wistar Rats (Oedema of the paw) |
| Dosage: | 100 mg/kg |
| Administration: | P.o. |
| Result: | Exerted a statistically significant dose-dependent antagonist action lasting throughout the 2-hr observation period. |