4452-06-6
4452-06-6 结构式
基本信息
中文别名
2'-萘丙烯酮2-萘乙烯基酮
英文别名
ZM 449829JAK3 INHIBITOR V
2'-Acrylonaphthone
naphthyl vinyl ketone
2-NAPHTHYLVINYL KETONE
1-Naphthalen-2-yl-propenone
1-(2-Naphthyl)-2-propen-1-one
1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE
1-(Naphthalen-2-yl)prop-2-en-1-one
2-Propen-1-one, 1-(2-naphthalenyl)-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点319.3±15.0 °C(Predicted)
密度1.093±0.06 g/cm3(Predicted)
储存条件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
形态白色蜡状固体
常见问题列表
生物活性
ZM 449829 是有效的、选择性和 ATP 竞争性的 JAK3 抑制剂，pIC50 值为 6.8。ZM 449829 是可用于研究 JAK3 的药理学工具。靶点
|
JAK3 6.8 (pIC 50 ) |
JAK1 4.7 (pIC 50 ) |
EGFR 5.0 (pIC 50 ) |
体外研究
ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC
50
=5.0) , Jak1 (pIC
50
=4.7), and tyrosine kinases Lck and CDK4 (pIC
50
<5.0).
ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation.
Western Blot Analysis
| Cell Line: | YTS, NK92, and ex vivo NK cells |
| Concentration: | 1 μM |
| Incubation Time: | 30 minutes pretreatment |
| Result: | Inhibits the phosphorylation of STAT5. |