| Identification | Back Directory | [Name]
ZM 449829 | [CAS]
4452-06-6 | [Synonyms]
ZM 449829
JAK3 INHIBITOR V
2'-Acrylonaphthone
naphthyl vinyl ketone
2-NAPHTHYLVINYL KETONE
1-Naphthalen-2-yl-propenone
1-(2-Naphthyl)-2-propen-1-one
1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE
1-(Naphthalen-2-yl)prop-2-en-1-one
2-Propen-1-one, 1-(2-naphthalenyl)-
JAK3 Inhibitor V - CAS 932258 - Calbiochem | [Molecular Formula]
C13H10O | [MDL Number]
MFCD04974535 | [MOL File]
4452-06-6.mol | [Molecular Weight]
182.22 |
| Chemical Properties | Back Directory | [Boiling point ]
319.3±15.0 °C(Predicted) | [density ]
1.093±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
White waxy solid | [color ]
white |
| Hazard Information | Back Directory | [Uses]
ZM 449829, is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Also inhibits STAT-5 phosphorylation and T-cell proliferation. | [Definition]
ChEBI: 1-(2-naphthalenyl)-2-propen-1-one is a member of naphthalenes. | [Biological Activity]
Cell permeable: no''Product does not compete with ATP.''Reversible: no''pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1 | [IC 50]
JAK3: 6.8 (pIC50); JAK1: 4.7 (pIC50); EGFR: 5.0 (pIC50) | [storage]
Desiccate at -20°C |
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