480-54-6
中文名称
倒千里光碱
英文名称
RETRORSINE
CAS
480-54-6
分子式
C18H25NO6
分子量
351.39
MOL 文件
480-54-6.mol
更新日期
2023/05/06 14:52:02
480-54-6 结构式
基本信息
中文别名
逆丙氨酸倒千里光碱
探讨倒千里光碱
倒千里光碱(>90%,BC)
英文别名
RetrosineRETRORSIN
RETRORSINE
Retrorcine
β-Longilobine
RETRORSINE(AS)
BETA-LONGILOBINE
cis-retronecicacidesterofretronecine
16-dione,12,18-dihydroxy-senecionan-1
12,18-DIHYDROXYSENECIONAN-11,16-DIONE
所属类别
分析化学：食品和化妆品标准品物理化学性质
熔点208-211 °C(lit.)
比旋光度D18 -17.6° (c = 1.99 in ethanol)
沸点485.2°C (rough estimate)
密度1.32±0.1 g/cm3 (20 ºC 760 Torr)
折射率1.5100 (estimate)
储存条件?20°C
酸度系数(pKa)12.00±0.40(Predicted)
形态neat
Merck13,8253
InChIKeyBCJMNZRQJAVDLD-VMOBWIEOSA-N
CAS 数据库480-54-6
(IARC)致癌物分类3 (Vol. 10, Sup 7) 1987
EPA化学物质信息Retrorsine (480-54-6)
安全数据
警示词危险
危险性描述H300+H310+H330
危险品标志T
危险类别码25
安全说明22-36/37/39-45
危险品运输编号1544
WGK Germany3
RTECS号VH7525000
危险等级6.1(a)
包装类别II
常见问题列表
生物活性
Retrorsine 是一种天然存在的有毒吡咯利西啶生物碱。Retrorsine 可以与 DNA 结合，抑制肝细胞的增殖能力。Retrorsine 可用于肝细胞损伤的研究。体外研究
Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability and GSH levels, and increases formation of pyrrole-protein adducts.
Cell Viability Assay
| Cell Line: | HSEC-CYP3A4 cells |
| Concentration: | 60 μM, 120 μM , 240 μM |
| Incubation Time: | 24 hours |
| Result: | Significantly decreased cell viability. |
体内研究
Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle.
| Animal Model: | Male Wistar rats (180±20 g), portal branch ligation (PBL) model |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection, twice, separated by 2-week interval |
| Result: | Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL. |