499-44-5
499-44-5 结构式
基本信息
桧木醇
日柏醇
Β-檜酚酮
Β-異丙【草(之上)+卓】酚酮
2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIEN-1-ONE
2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIENE
2-HYDROXY-4-ISOPROPYLCYCLOHEPTA-2,4,6-TRIEN-1-ONE
4-ISOPROPYLTROPOLONE
BETA-THUJAPLICIN
BETA-THUJAPLICINE
B-THUJAPLICIN
HINOKITIOL
2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-isopropyl-
6-cycloheptatrien-1-one,2-hydroxy-4-(1-methylethyl)-4
6-cycloheptatrien-1-one,2-hydroxy-4-isopropyl-4
beta-Isopropyltropolon
beta-Isopropyltropolone
Hinokitol
Thujaplicin, beta
Tropolone, 4-isopropyl-
2-hydroxy-4-isopropyl-2,4,6-cyclohepta-2,4,6-trien-1-one
2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-
Isopropyltropolone
物理化学性质
常见问题列表
2，从香芹酮经环氧化、缩醛化等六步反应合成桧木醇。
3，从异丙基环己酮或异丙基环己烯酮经转变成羟基腈，两步制成异丙基环庚酮，再经氧化、溴化、脱溴化氢制备。
4，溴代环庚三烯酮与一种有机物反应，然后催化氢化合成。
5，从环戊二烯与一个二氯烯酮加成制成异丙基环戊二烯，再进行溶剂解，经三步反应合成桧木醇。
前四种制备方法合成路线步骤太多或原料难以得到，实际上无法工业生产。因此近年来主要集中在第五种合成方法的研究。
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DNMT1
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Nrf2
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In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC 50 values of 316.5 ± 35.5 and 152.5 ± 25.3 µM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT , CHST10 , and BTG4 genes.