509-15-9
509-15-9 结构式
基本信息
胡曼鹼
钩吻碱
钩吻宁
钩吻碱钾
钩吻素甲
钩吻素碱
钩吻碱甲
常绿黄素馨碱
钩吻碱对照品,
GESEMINE
GELSAMINE
GELSEMINE
gelsemine free base
3h)indol)-2’(1’,h)-one
8abeta,9s*,10s*))-8alph
Gelsemine, 98%, from Gelsemium elegans (Gardner & Chapm.) Benth.
ne,5-ethenyl-3,4,4a,5,6,7,8,8a-octahydro-7-methyl-,(3r-(3alpha,4abeta,5alpha,
spiro(3,5,8-ethanylylidene-1h-pyrano(3,4-c)pyridine-10,3’-(3h)indol)-2’(1’h)-o
物理化学性质
安全数据
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-N0388 | 钩吻碱 Gelsemine | 509-15-9 | 5mg | 600元 |
| 2024/01/25 | HY-N0388 | 钩吻碱 Gelsemine | 509-15-9 | 10mM * 1mLin DMSO | 660元 |
| 2024/01/25 | HY-N0388 | 钩吻碱 Gelsemine | 509-15-9 | 10mg | 960元 |
常见问题列表
Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice.
Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%.