509102-00-5
中文名称
4-[[[2-(环己基亚氨基)-4-甲基-3(2H)-噻唑基]亚氨基]甲基]-1,2,3-苯三醇
英文名称
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
CAS
509102-00-5
分子式
C17H21N3O3S
分子量
347.43
MOL 文件
509102-00-5.mol
509102-00-5 结构式
基本信息
中文别名
MCL-1抑制剂(MIM1)4-[[[2-(环己基亚氨基)-4-甲基-3(2H)-噻唑基]亚氨基]甲基]-1,2,3-苯三醇
英文别名
MIM1CS-1192
MIM 1
MIM-1
Inhibitor of Mcl-1
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol
1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-
物理化学性质
沸点559.6±60.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
溶解度insoluble in EtOH; insoluble in H2O; ≥12.15 mg/mL in DMSO
酸度系数(pKa)7.73±0.45(Predicted)
常见问题列表
生物活性
MIM-1 是一种骨髓细胞因子 1 (Mcl-1) 抑制剂。靶点
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Mcl-1
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体外研究
MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC 50 value. The IC 50 value of the HA cell line is almost 5-fold lower (16.10 µM) compared with the IC 50 of the T98G cell line (80.20 µM) after MIM-1 inhibitor treatment.