518-69-4
518-69-4 结构式
基本信息
紫堇碱
延胡索碱
延胡索碱甲
延胡索甲素
紫堇碱,延胡索碱,
延胡索甲素(紫堇碱)
延胡索甲素(标准品)
延胡索碱(紫堇块茎碱)
(+)-紫堇碱,延胡索甲素
CORYDALINE
Corydalis A
(13s-e)-thyl
d-Corydaline
(+) CORYDALINE
Corydaline std.
CORYDALINE, (+)
2,3,9,10-tetramethoxy-13-methyl-berbin
2,3,9,10-TetraMethoxy-13-Methylberbine, 8CI
物理化学性质
安全数据
常见问题列表
延胡索甲素为季胺类生物碱，是罂粟科紫堇属植物延胡索(Corydalis yanhusuo W.T.Wang)块茎中的主要有效成分之一。现代药理学表明延胡索甲素不仅有镇痛、兴奋子 宫、抗心律失常等作用，延胡索甲素具有抗吗啡样作用，还可用于制备为戒毒药物。
延胡索甲素在无毒性范围内能够有效地抑制呼吸道病毒的复制，可进一步开发为治疗或预防病毒性呼吸道疾病的药物，具有广泛的应用前景。
IC50: 226 µM (AChE); 25.23 µM (Enterovirus 71)
Ki: 1.23 µM (μ-opioid receptor)
Corydaline (12.5-50 µM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro.
Corydaline could inhibit the viral RNA synthesis in a dose dependent manner.
Western Blot Analysis
| Cell Line: | Vero cells infected with EV71 |
| Concentration: | 12.5 µM, 25 µM, 50 µM |
| Incubation Time: | 24 hours |
| Result: | Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2. |
Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior.
| Animal Model: | Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid |
| Dosage: | 10 mg/kg |
| Administration: | Subcutaneous administration; once |
| Result: | Showed antinociceptive effects in mice. |