| Identification | Back Directory | [Name]
Corydaline | [CAS]
518-69-4 | [Synonyms]
corydalin
CORYDALINE
Corydalis A
d-Corydaline
(13s-e)-thyl
(+) CORYDALINE
CORYDALINE, (+)
Corydaline std.
2,3,9,10-tetramethoxy-13-methyl-berbin
2,3,9,10-TetraMethoxy-13-Methylberbine, 8CI
2,3,9,10-tetramethoxy-13-alpha-methyl-13a-beta-berbin
6h-dibenzo(a,g)quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-me
[7S,13S,13aR,(+)]-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine | [Molecular Formula]
C22H27NO4 | [MDL Number]
MFCD00076019 | [MOL File]
518-69-4.mol | [Molecular Weight]
369.45 |
| Chemical Properties | Back Directory | [Melting point ]
135° | [alpha ]
D20 +311° (c = 0.8 in alc) | [Boiling point ]
499.57°C (rough estimate) | [density ]
1.1771 (rough estimate) | [refractive index ]
1.5614 (estimate) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
6.57±0.40(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1 | [InChIKey]
VRSRXLJTYQVOHC-YEJXKQKISA-N | [SMILES]
C12=CC(OC)=C(OC)C=C1CCN1[C@]2([H])[C@@H](C)C2=CC=C(OC)C(OC)=C2C1 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the tubers of Corydalis yanhusuo, the whole herb of Corydalis koizumi, the root of Corydalis fushun, and the tubers and aerial parts of Corydalis malcha. | [Uses]
Corydaline is a common herbal drug used in Chinese medicine and is touted as an analgesic with reported anti-angiogenic effects. | [Definition]
ChEBI: Corydaline is an isoquinoline alkaloid and a member of isoquinolines. | [in vivo]
Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior[3]. | Animal Model: | Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid[3] | | Dosage: | 10 mg/kg | | Administration: | Subcutaneous administration; once | | Result: | Showed antinociceptive effects in mice. |
| [IC 50]
AChE; μ Opioid Receptor/MOR |
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