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526-31-8

中文名称 相思豆毒素
英文名称 L-ABRINE
CAS 526-31-8
EINECS 编号 208-388-5
分子式 C12H14N2O2
MDL 编号 MFCD00005645
分子量 218.25
MOL 文件 526-31-8.mol
更新日期 2024/04/28 11:56:08
526-31-8 结构式 526-31-8 结构式

基本信息

中文别名
相思豆毒素
英文别名
1-METHYL-L-TRYPTOPHAN
ABRINE
ABRINE, L-
H-METRP-OH
L-ABRINE
N ALPHA-METHYL-L(+)-TRYPTOPHAN
N-ALPHA-METHYL-L-TRYPTOPHAN
N-A-METHYL-L-TRYPTOPHAN
N-METHYL-L-TRYPTOPHAN
N-METHYL-L-TRYPTOPHANE HYDROCHLORIDE
N-METHYLTRYPTOPHAN
N-ME-TRP-OH
N-ME-TRP-OH HCL
N-ME-TRYPTOPHAN
N-alpha-Methyl-L-trytophan
(2S)-2-(Methylamino)-3-(1H-indole-3-yl)propanoic acid
(S)-3-(1H-Indol-3-yl)-2-(methylamino)propionic acid

物理化学性质

熔点>300 °C (dec.)(lit.)
比旋光度D21 +44° (0.28 g in 10 ml 0.5N HCl)
沸点358.94°C (rough estimate)
密度1.272±0.06 g/cm3 (20 ºC 760 Torr)
折射率65 ° (C=1, 0.5mol/L NaOH)
储存条件under inert gas (nitrogen or Argon) at 2–8 °C
溶解度H2O : 2 mg/mL (9.16 mM; ultrasonic and adjust pH to 10 with NaOH)
酸度系数(pKa)2.32±0.10(Predicted)
形态Cryst.
旋光性 (optical activity)[α]20/D +65°, c = 1 in 0.5 M NaOH
Merck10
BRN86638

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H302+H312+H332
危险品标志Xn
危险类别码R20/21/22
安全说明S36
WGK Germany3
海关编码29339900

应用领域

用途1
一种在体外表现出自由基清除和抗氧化剂特性的吲哚氨基酸。
相思豆毒素价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/01/16S5828相思豆毒素
L-Abrine
526-31-825mg1204.73元
2018/06/12A1489L-红豆碱
L-Abrine
526-31-8200MG375元
2018/06/12A1489L-红豆碱
L-Abrine
526-31-81G1120元

常见问题列表

生物活性
L-Abrine (N-Methyl-L-tryptophan)是相思子根部的毒性清蛋白,可抑制核糖体。
体外研究

L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine.

体内研究

Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD 50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD 50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment.

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