533902-29-3
533902-29-3 结构式
物理化学性质
沸点1024.2±65.0 °C(Predicted)
密度1.185±0.06 g/cm3(Predicted)
酸度系数(pKa)3.30±0.10(Predicted)
形态Solid
颜色White to off-white
ANXA2抑制剂多肽价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-P2333 | ANXA2抑制剂多肽 LCKLSL | 533902-29-3 | 1 mg | 1000元 |
| 2025/02/08 | HY-P2333 | ANXA2抑制剂多肽 LCKLSL | 533902-29-3 | 5mg | 2500元 |
| 2025/02/08 | HY-P2333 | ANXA2抑制剂多肽 LCKLSL | 533902-29-3 | 10mg | 4500元 |
常见问题列表
生物活性
LCKLSL 是一种 N 末端六肽，是一种竞争性的膜联蛋白 A2 (AnxA2) 抑制剂，可有效抑制组织纤溶酶原激活物 (tPA) 与 AnxA2 的结合。LCKLSL 还可抑制纤溶酶的产生，并具有抗血管生成的作用。靶点
Annexin A2 (AnxA2)
体外研究
In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions.
体内研究
Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points.