25849-90-5
CAS
25849-90-5
分子式
C42H57N9O9
25849-90-5 结构式
常见问题列表
生物活性
TRV055 是 1 型血管紧张素 II 受体 (AT1R) 的 Gq-偏置的配体。TRV055 有效刺激细胞 Gq 介导的信号传导。TRV055 可用于开发 Gq-偏置的 AT1R 激动剂。体外研究
TRV055 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling.