54237-72-8
中文名称
西咪替丁亚砜盐酸盐
英文名称
CIMETIDINE SULPHOXIDE DIHYDROCHLORIDE
CAS
54237-72-8
分子式
C10H16N6OS
分子量
268.34
MOL 文件
54237-72-8.mol
更新日期
2024/04/24 18:23:17
54237-72-8 结构式
基本信息
中文别名
西咪替丁亚砜西咪替丁杂质E
西咪替丁EP杂质E
西咪替丁亚砜盐酸盐
西咪替丁杂质E(EP)
)-西咪替丁 S-氧化物
(±)-西咪替丁 S-氧化物
西咪替丁杂质E(EP) 标准品
英文别名
SKF-92452Cimetidine S-oxide
cimetidine sulfoxide
Cimetidine impurity E
Cimetidine EP Impurity E
Cimetidine Impurity E(EP)
2-Cyano-1-methyl-3-[2-[[(5-methyl-1
CIMETIDINE SULPHOXIDE DIHYDROCHLORIDE
Cimetidine Impurity 5(Cimetidine EP Impurity E)
CIMETIDINE EP IMPURITY E (CIMETIDINE SULPHOXIDE)
所属类别
有机原料:羧酸类化合物及衍生物物理化学性质
熔点>180°C (dec.)
沸点594.8±60.0 °C(Predicted)
密度1.39±0.1 g/cm3(Predicted)
储存条件-20°C冷冻
溶解度DMSO(微溶,加热)、甲醇(微溶)
酸度系数(pKa)13.38±0.10(Predicted)
形态固体
颜色白色至灰白色
常见问题列表
生物活性
Cimetidine sulfoxide (Cimetidine sulphoxide) 是一种 Cimetidine 的亚砜代谢产物。Cimetidine 是一种组胺 H2 受体 (H2-receptor) 拮抗剂,可用于消化性溃疡和上消化道出血的研究。靶点
Histamine H 2 -receptor
体外研究
Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations (40 and 200 μM), but is masked by passive transfer at higher concentrations (400 μM). Cimetidine sulfoxide is detected after some incubations.
体内研究
The enantiomeric composition of Cimetidine sulfoxide is also determined in rat urine (24 h) following the administration of Cimetidine (30 mg/kg; po) to male Wistar rats. The enantiomeric ratio in this case is found to be (+/−) 57:43.